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- 04/26/2017

HAIRGENYL® – Trigger hair dynamics to regain density

H&PC Today

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HAIRGENYL® is an anti-hair loss active ingredient, which supports the biological activity of the dermal papilla and stimulates hair follicle growth to re-normalize hair development.

AT THE HEART OF HAIR FOLLICLE BIOLOGY

Androgenetic alopecia is the result of a deregulation of the hair growth cycle, mainly affecting men and leading to gradual hair loss.

SILAB specifically developed 2D and 3D cell and tissue models mimicking the androgenetic alopecia to identify and demonstrate the efficacy of HAIRGENYL® on the dermal papilla.

At the heart of hair follicle biology, HAIRGENYL® targets three regulators of hair growth. With HAIRGENYL®, SILAB demonstrates for the first time that increasing mitochondrial fusion boosts the capacity for energy production that is used for growth of the hair follicle [1]. Also, HAIRGENYL® corrects the abnormal expression of signaling molecules [2] and epigenetics [3] involved in androgenetic alopecia.

[1] Tested at 0.04% on human hair follicle dermal papilla cells, HAIRGENYL® stimulates the synthesis of mitofusin 1 by +52%.
[2] Tested on human hair follicle dermal papilla cells treated with DHT, HAIRGENYL® at 0.04% limits the expression of IL-6 by -97% and the expression of DKK1 and of P16 by -91% and -71% respectively.
[3] Tested on human hair follicle dermal papilla cells treated with DHT, HAIRGENYL® at 0.04% limits the expression of 3663-3p miRNA and let-7a-3p by -50% and -89% respectively.

 

 

ANTI-HAIR LOSS AND REGROWTH EFFECT

Tested over 8 months on a group of male volunteers, HAIRGENYL® increases hair density (+24.9%), hair growth (anagen/telogen ratio) (+112.7%) and limits hair loss (-34.0%) [4].
The majority of volunteers consider their hair becomes thicker (85%), more resistant (95%) and the scalp is more densely covered (85%).
By restoring the density of the hair, HAIRGENYL® is the strategy of choice for anti-loss and regrowth actions.

[4] HAIRGENYL® formulated at 0.3% in a lotion.

 

 

 

100% BIOTECHNOLOGICAL

SILAB offers a natural patented solution, developed with its expertise in biotechnologies.
Obtained from the yeast Pichia minuta, isolated from the flowers of azalea Rhododendron indicum and manufactured in SILAB’s production unit dedicated to biotechnologies, HAIRGENYL® is rich in biopeptides with low molecular weight and is the result of a nondenaturing production process.
A preservative-free powder, HAIRGENYL® (INCI name: Yeast Extract) is soluble in water, easy to formulate (recommended amount: 0.05 to 0.5%) and compliant with global cosmetic regulations (Europe, United Stated, Japan and China).