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Advantage of using chemically stable silica material in reversed phase chromatography at elevated pH

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Reversed phase chromatography is the most common techniques for screening and purification of peptides and the mobile phase pH plays an important role in preparative purification of APIs. Traditional silica-based materials in reversed phase chromatography are however often limited to be operated in the pH range between 2 and 8, and exclude the possibilities to use high pH to achieve high purity and yield. A chemically stable organic/inorg