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Application of bioactive peptides for relief of inflammatory skin conditions

KATIE RODAN1, KATHY FIELDS1, LORI BUSH1*, TIMOTHY FALLA2
*Corresponding author
1. Rodan + Fields Dermatologists, 111 Maiden Lane, Suite 400, San Franscisco, CA 94108, USA
2. Helix BioMedix Inc., 22118 20th Ave SE, Suite 204, Bothell, WA 98021, USA

Abstract

Skin inflammation may be the manifestationof an underlying physiological condition, result fromexposure to environmental triggers or, as is often thecase, be due to a combination of both endogenous andexogenous factors. Numerous pharmacological agentslisted in the OTC Monograph for skin protectant drugproducts for human use help to manage inflammatoryskin conditions by bulking the stratum corneum forenhanced barrier competency, thus helping to modulateskin’s inflammatory processes. Here we propose that, byadding a combination of bioactive peptides and otheractive cosmetics to an OTC skincare formulation, themicro-environment of skin’s surface may be furthermodulated to support the benefits derived fromtraditional skin protectant agents.