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Beneficial actions of fi sh protein in cardiovascular diseases

UND Life Sciences
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Epidemiological studies suggested that dietary saturated fats play a signifi cant role in coronary heart disease (CHD). Diets high in long-chain polyunsaturated fatty acids (PUFAs), especially α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are benefi cial in CHD prevention (1). Studies performed in experimental animals revealed that diets rich in ALA, EPA, and DHA diminish atherosclerosis, reduce the tendency to arterial thrombosis; lower the ability of platelets to aggregate and decrease the incidence of cardiac arrhythmias. The mechanisms by which these diets produce these effects are not yet completely understood. But, it is believed that PUFAs are metabolized to form anti-infl ammatory eicosanoids such as prostaglandin E1 (PGE1), prost