Continuous API manufacturing in pharma – Where are we today and where will we be in ten years?
Drivers for the pharmaceutical industry to move API production from batch to continuous are commonly seen as being much weaker than for the commodity chemical industry. The production volumes of APIs are considerably less than those of bulk chemicals and product lifecycles are often short. Furthermore, most APIs are significantly more complex than commodity chemicals and their production usually requires many synthetic steps in addition to multiple cycles of isolation and purification. The complexity and diversity of these molecules, and the consequent multifaceted and diverse process conditions required for their synthesis and isolation, generally demand flexible, multipurpose reaction vessels for their production. Stirred tank-reactors are easy to handle and can be employed for