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Copper-Catalysed N-alkynylation of  benzimidazoles and indazoles

KÉVIN JOUVIN, GWILHERM EVANO*
*Corresponding author
Institut Lavoisier de Versailles, UMR CNRS 8180, Université de Versailles Saint-Quentin en Yvelines, 45, avenue des Etats-Unis, Versailles Cedex, 78035, France

Abstract

We have successfully shown that readily availablevinyl dibromides in combination with copper catalysisare especially effi cient and useful reagents for thealkynylation of benzimidazoles and indazoles. This processallows the direct and straightforward synthesis of a varietyof heterocyclic ynamines, which are otherwise diffi cult toaccess and which may provide interesting platforms indrug discovery and material science as well.