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P. 77-82 /

Different chemically substituted chitooligosaccharides inhibit β-secretase activity

A. BAKRUDEEN ALI AHMED1,2*, N.Y. YOON1, ROSNA MAT TAHA2, S.K. KIM1
*Corresponding author
1. Pukyong National University Marine Bioprocess Research Center Busan, South Korea
2. University of Malaya, Institute of Biological Sciences, Faculty of Science, Kuala Lumpur, 50603, Malaysia

Abstract

Chitooligosaccharide or COS is a kind of oligosaccharide thatis an integral part of the nervous system. COS is synthesizedby chemical substitution and derived AE-COS, DEAE-COSand DMAE-COS that are being shown on IC50 value. AE-COSand DMAE-COS exhibited four fold less inhibition than DEAECOS.In addition, non-competitive inhibitor was identified viaa Dixon plot and the Ki inhibition constant (100 μg/mL).We declared, chemical substitution of COS is a water solublehuman safe BACE-1 inhibitor.