Developing flow photochemistry, especially at meso-scale where significant productivity is required, remains challenging. There is a need for innovative equipments generating highly controlled flow under light irradiation. In this work, a commercial solution, developed by Corning, is presented and studied by LGC and MEPI on an intramolecular (2+2) photo-cycloaddition. Detailed experimental and modelling analysis has been performed to emphasize the flow reactor behaviour and performances, and demonstrate its capability in producing up to 30g.h-1 of the desired molecule. Through this simple model reaction, the G1 photo-reactor is shown to be an efficient meso-scale reactor for industrial photo-applications development and production.

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Flowphotochemistry:a meso-scale reactor for industrial applications

corresponding

SÉBASTIEN ELGUE1,2,3*, TRISTAN AILLET2,3, KARINE LOUBIERE2,3, ANNELYSE CONTÉ1, ODILE DECHY-CABARET2,4, LAURENT PRAT2,3, CLEMENS R. HORN5, OLIVIER LOBET5, SOPHIE VALLON5
* Corresponding author
1. MEPI – Plate-forme SAFRAN-HERAKLES, Chemin de la Loge, CS 27813, 31078 Toulouse Cedex 4, France
2. Université de Toulouse; INPT, ENSIACET, F-31432 Toulouse, France
3. CNRS, Laboratoire de Génie Chimique (LGC UMR 5503); 4 allée Emile Monso, BP 84234, F-31432 Toulouse, France
4. CNRS, Laboratoire de Chimie de Coordination (LCC UPR 8241), 205 route de Narbonne, BP 44099, F-31077 Toulouse, France
5. Corning S.A.S., Corning European Technology Center, 7 bis avenue de Valvins, CS 70156 Samois sur Seine, 77 215 Avon Cedex, France

Abstract

Developing flow photochemistry, especially at meso-scale where significant productivity is required, remains challenging. There is a need for innovative equipments generating highly controlled flow under light irradiation. In this work, a commercial solution, developed by Corning, is presented and studied by LGC and MEPI on an intramolecular (2+2) photo-cycloaddition. Detailed experimental and modelling analysis has been performed to emphasize the flow reactor behaviour and performances, and demonstrate its capability in producing up to 30g.h-1 of the desired molecule. Through this simple model reaction, the G1 photo-reactor is shown to be an efficient meso-scale reactor for industrial photo-applications development and production.


 

 Introduction

Since the last decade, Process Intensification opens up interesting perspectives for the Fine Chemical and Pharmaceutical industries. A wide range of che