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Friedel-Crafts acylation reaction with anhydrides Silica supported sulfonic acids as green and efficient heterogeneous catalysts

CALOGERO G. PISCOPO*, ANDREA ADORNI, RAIMONDO MAGGI, GIOVANNI SARTORI
*Corresponding author
“Clean Synthetic Methodologies Group”Dipartimento di Chimica Organica e Industriale dell’UniversitàConsorzio Interuniversitario “La Chimica per l’Ambiente” (INCA)UdR PR2, Parco Area delle Scienze 17, Parma 43124, Italy

Abstract

Since the first paper reported by Friedel and Crafts, theacylation reaction quickly became a fundamental pillarof synthetic organic chemistry at both the academic andindustrial levels. In particular, maximum effort has beendirected toward the use of solid acid catalysts. Recentlythe acylation of anisole with acetic anhydride has beencarried out with good yield and excellent selectivityby using sulfonic acids tethered onto silica as catalysts.In this work we show the study dealing with the role ofdifferent silica supported sulfonic acids in the acylation ofaromatics with acetic anhydride, in order to evaluate theeffect of the textural properties of the catalysts.