Highly efficient palladium-catalyzed arsination
On the way to arsine ligands
Since arsines are drawingparticular attention as ligands inmetal-catalyzed reactions, the development of new methodsto obtain organoarsines is increasingly recognized as central inthe synthesis of new ligands. Transition metal-catalyzedreactions with organoheteroatom compounds are widely usedto acquire different heteroatom-contained compounds. Thisarticle reviews a highly efficient one-pot, two-stepPd-catalyzed arsination with n-Bu3SnAsPh2 and diverseelectrophiles. The cross-coupling reactions of these stannaneswith ArI afforded the functionalized triarylarsines, and with RfIas electrophiles new perfluoroalkylarsines were achieved. Byfollowing this methodology, a biphenyl arsine ligand wasacquired. The use of the commercially available, air-stable,and inexpensive AsPh3 as the initial reagent and the one-potprocess make this methodology a useful approach toobtaining a wide range of organoarsines.