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Hydrocarbon stapled peptides

WILLIAM D. BENNETT
Chemical and Peptide Products, AAPPTec, LLC

INTRODUCTION
Hydrocarbon stapled peptides have important potential in the development of peptide drugs. Peptides have high potency, high specificity and few side effects, but are rapidly degraded by protease enzymes.  The hydrocarbon cross links of stapled peptides constrain the peptide in an a-helix conformation, favoring binding for peptides that bind to their receptor in an a-helix conformation.  Additionally, in a helical structure, the polar amide backbone is less exposed producing greater resistance to protease enzymes and increased penetration of cell membranes.   Double stapling of an HIV-1 fusion inhibitor greatly improved its pharmacokinetic properties, including oral availability. (1)

 

STAPLED PEPTIDES AS POTENTIAL DRUG LEADS