Ionic liquids Toxic or not?
Ionic liquids received a bad press in the early days when it was discovered that imidazolium and pyridinium salts with long alkyl substituents were extremely toxic. Now that ionic liquid structure-activity relationships are better understood, it is possible to design new, task-specific ionic liquids to span the entire toxicity range, from biocides right through to non-toxic, environmentally benign ionic liquids. Thus, there is nothing special about ionic liquid toxicology: just like any other group of chemicals, some are toxic and some are not
THE BEGINNINGS OF IONIC LIQUID TOXICOLOGY
Until very recently, imidazolium derivatives had rarely found application either as building blocks or commercial products (1), so there had been little previous incentive to study their toxicology or even their broader impact in our environment. In the 1990s, it was realised that ionic liquids represented a “Green” alternative to conventional, more volatile, molecular solvents (2). This prompted an explosion of research effort at record breaking pace and with unprecedented productivity, based on the application of archetypical 1,3-dialkylimidazolium-based salts (2, 3). Consequently, the “new” ionic liquids represented “virgin territory” for toxicity studies, and they immediately began to capture the attentio