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Mastering ozonolysis: production from laboratory to ton scale in continuous flow

MARKUS NOBIS, DOMINIQUE M. ROBERGE
Lonza AG, Visp, 3930, Switzerland

Abstract

In most cases, ozonolysis is more sustainable and costeffective for the oxidative treatment of organic unsaturatedcompounds than other oxidation technologies. To enable thescalability of this challenging gas-liquid oxidation process, Lonzahas developed a novel approach that combines microreactors,a bench-scale reactor, and a large scale production reactor.The approach also includes laboratory feasibility studiesand technical transfer – with hazard evaluations and safetyassessments – to successful large scale manufacturing.