Print this article

Nutraceuticals molecular targets (III) – Targeting protein receptors with polyphenols as new anti-obesity therapies

corresponding

VICENTE MICOL, Ph.D, JOSÉ ANTONIO ENCINAR, Ph.D, MARÍA HERRANZ, Ph.D
Universidad Miguel Hernández (UMH), Instituto de Biología Molecular y Celular (IBMC),Elche (Alicante), Spain

In the previous column, we proposed the use of a global scientific approach to elucidate the beneficial effects of plant polyphenols and other dietary compounds on human health (1). This approach included: i) the identification of the metabolites derived from food components that are responsible for the health effects and the associated metabolic markers; ii) the elucidation of their protein targets and concomitant metabolic pathways; iii) in silico techniques to screen for millions of compounds against the known molecular targets and finding for new candidates; iv) appropriate cellular and animal models to verify the mechanism of action and toxicity; v) human trials to demonstrate the beneficial effects associated to specific compounds. Although this strategy may be appropriate,