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Pharma and suppliers collaborating on Green Chemistry Launch of PMI tool

QUIRINUS B. BROXTERMAN1*, DAVID L. HUGHES2*, WILLIAM D. PYRZ2
*Corresponding authors
1. DSM Innovative Synthesis B.V., P.O. Box 18 ,Geleen, 6160 MD, The Netherlands
2. Merck and Co.Inc., PO Box 2000, Rahway, NJ 07065, USA

Abstract

The ACS GCI Pharmaceutical Roundtable is a partnershipof the American Chemical Society’s (ACS) GreenChemistry Institute® and 16 pharmaceutical and finechemical companies that have joined forces to drive theimplementation of green chemistry and engineering acrossthe global pharmaceutical industry. A straightforwardprocess mass intensity (PMI) tool has been developed andadopted by the Roundtable for use throughout the industry.The purpose of this article is to introduce the PMI calculatortool to pharma suppliers to facilitate calculation of PMI’sfor intermediates and active pharmaceutical ingredients(API’s) they provide to their pharma customers. The PMIdata will thus provide a measure of the greenness of achemical process starting from commodity raw materials.