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Process technology for the application of d-amino acid oxidases in pharmaceutical intermediate manufacturing

STUART R TINDAL1, REUBEN CARR2, IAN V J, ARCHER2, JOHN M WOODLEY1*
*Corresponding author
1. Technical University of Denmark, Center for Process Engineering and Technology, Department of Chemical and Biochemical Engineering, Lyngby, DK-2800, Denmark
2. Ingenza Ltd, Roslin BioCentre, Roslin, EH25 9PP, Scotland, United Kingdom

Abstract

Recent advances in biocatalysis have seen increased interest inthe use of D-amino acid oxidase to synthesize optically pure aminoacids. However, the creation of a genuine oxidase–based platformtechnology will require suitable process technology as well as anunderstanding of the challenges and opportunities of a wider portfolioof synthetic targets. In this article we address some of the recentprogress in process technology to enable the future development of ageneric platform technology.