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Soy protein lowers cholesterol without increasing bile acid excretion in subjects with moderate hypercholesterolemia

KEVIN C. MAKI*1, DUSTIE N. BUTTEIGER2, TIA M. RAINS1, ANDREA L. LAWLESS1, MATTHEW S. REEVES1, CHUCK SCHASTEEN2, ELAINE S. KRUL2
*Corresponding author
1. Provident Clinical Research, Inc., 489 Taft Avenue, Glen Ellyn, IL 60137, USA
2. Solae LLC, 4300 Duncan Avenue, St. Louis, MO, 63110, USA

ABSTRACT: Soy protein (SP) has well-described cholesterol-lowering effects, but the mechanisms responsible are not well understood. We conducted a trial that evaluated the effects of 25 g/d of an insoluble fraction of SP or total milk protein (TMP) on
fasting lipids and investigated the possible role of increased bile acid excretion in mediating these lipid responses. SP and TMP, respectively, reduced total cholesterol (-7.4 and -3.6 percent), low-density lipoprotein cholesterol (LDL-C) (-10.9 and -5.9 percent), and non-high-density lipoprotein cholesterol (-10.8 and -3.9 percent), (p < 0.05 for between group differences except LDL-C, p = 0.085). Fecal bile acid and neutral sterol excretion were not increased with either protein source. These fi ndings confi r