Soy protein lowers cholesterol without increasing bile acid excretion in subjects with moderate hypercholesterolemia
KEVIN C. MAKI*1, DUSTIE N. BUTTEIGER2, TIA M. RAINS1, ANDREA L. LAWLESS1, MATTHEW S. REEVES1, CHUCK SCHASTEEN2, ELAINE S. KRUL2
*Corresponding author
1. Provident Clinical Research, Inc., 489 Taft Avenue, Glen Ellyn, IL 60137, USA
2. Solae LLC, 4300 Duncan Avenue, St. Louis, MO, 63110, USA
fasting lipids and investigated the possible role of increased bile acid excretion in mediating these lipid responses. SP and TMP, respectively, reduced total cholesterol (-7.4 and -3.6 percent), low-density lipoprotein cholesterol (LDL-C) (-10.9 and -5.9 percent), and non-high-density lipoprotein cholesterol (-10.8 and -3.9 percent), (p < 0.05 for between group differences except LDL-C, p = 0.085). Fecal bile acid and neutral sterol excretion were not increased with either protein source. These fi ndings confi rm that SP has a hypocholesterolemic effect, but this does not appear to be attributable to increased fecal bile acid excretion. ...
