This article provides an overview on reagents and protocols for the synthesis of aromatic trifluoromethyl compounds. The generation of trifluoromethylated aromatic building blocks, the deoxoflurination of carboxylic acids, and the trifluoromethylation of aromatic precursors are covered by this review. Issues that favor or hinder the large scale application of particular reagents and protocols are presented. Remarkably, only one out of more than 10 protocols covered by this review is currently applied on large production scale, a few others have been applied on a 5 kg to 100 kg scale.

" /> Synthesis of aromatic trifluoromethyl compounds: The potential for large scale application – TKS Publisher
Print this article
P. 26-37 /

Synthesis of aromatic trifluoromethyl compounds: The potential for large scale application

corresponding

HEINZ STEINER
Solvias AG, Römerpark 2, 4303 Kaiseraugst, Switzerland

Abstract

This article provides an overview on reagents and protocols for the synthesis of aromatic trifluoromethyl compounds. The generation of trifluoromethylated aromatic building blocks, the deoxoflurination of carboxylic acids, and the trifluoromethylation of aromatic precursors are covered by this review. Issues that favor or hinder the large scale application of particular reagents and protocols are presented. Remarkably, only one out of more than 10 protocols covered by this review is currently applied on large production scale, a few others have been applied on a 5 kg to 100 kg scale.


 

INTRODUCTION

Login to read the full article and download the PDF