Five minutes at FI Europe with …
Agro Food Industry Hi-Tech: What is Peptan and what does it mean for your company?
Lisette van Lith: Peptan collagen peptide is a protein extracted from natural collagen with multiple health benefits. Peptan has shown proven performance in several areas: healthy aging, joint and bone health, but also skin -so following the trend of “beauty from within” and it can be part of a healthy life style.
AF: What kind of formulations does Peptan enter?
LVL: Peptan, being hydrolyzed collagen, is very soluble and as such very versatile. Our customers make different formulations with it, depending on the specific use, from functional foods, to sport nutrition, to OTC formulations. In countries like Japan it tends to be consumed directly with food, while in the Western markets it is often formulated as powders that users can blend into drinks or food as they please – this is especially true in the US, also thanks to the paleo trend. For formulations focused on joint health, often it is combined with anti-inflammatory ingredients, while in cosmeceutical formulations it can be combined with antioxidants.
AF: What kind of research went into this product?
LVL: We have an R&D full team in Ghent (Belgium) devoted to the science of this product and we also
work with external and independent Research Institutes. We use the highest available standards, by testing in vitro, in vivo up to full clinical trials with placebo comparison. It is a bit like the lifecycle of a pharma product.
AF: What advantages did you find?
LVL: The collagen peptides act as building blocks to support our health. It has been proposed that collagen peptides may act as a messenger to the cells and trigger the synthesis and reorganization of new collagen fibers, therefore supporting skin tissue structure.
Peptan simultaneously promotes all our connective tissues by stimulating local cells in the target tissues to produce more collagen and other key matrix components. A wide range of studies has demonstrated its benefits for healthy and flexible joints [1,2] and strong bones [3,4,5,6]. Collagen peptides also support lean muscle mass and strength .
In terms of skin beauty, Peptan’s multiple anti-aging benefits are well-documented. In several clinical studies [8,9] visible effects have been demonstrated after just one month of use. Peptan can counteract the effects of aging and promote a more youthful appearance by boosting and restructuring the skin’s collagen network from within. By stimulating the production of hyaluronic acid, Peptan also offers skin hydration benefits.
- Jiang J.X. et al., 2014, Collagen peptides improve knee osteoarthritis in elderly women: A 6-month randomized, double-blind, placebo-controlled study. Agro FOOD Industry Hi Tech, 25:19-23
- Dar, Q. et al., 2017. Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis. PLoS ONE 12(4):e0174705
- Guillerminet, F. et al., 2010, Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: An in vitro and in vivo study. Bone, 46:827-834
- Guillerminet, F. et al., 2012, Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice. Osteoporosis International, 23(7):1909-1919
- Daneault, A. et al., 2014, Hydrolyzed collagen contributes to osteoblast differentiation in vitro and subsequent bone health in vivo. Osteoarthritis and Cartilage, 22:S131
- Daneault, A. et al., 2017, Biological effect of hydrolyzed collagen on bone metabolism. Critical Reviews in Food Science and Nutrition, 57(9):1922-1937
- Hays N.P. et al., 2009, Effects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older women. Journal of the American Dietetic Association, 109:1082-1087.
- Asserin, J. et al., 2015. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, 14:291-301. doi: 10.1111/jocd.12174
- Borumand, M. et al., 2014, Daily consumption of the collagen supplement Pure Gold Collagen® reduces visible signs of aging, Clinical Interventions in Aging. 9:1747-17
AF: Is Peptan part of a larger health nutrition strategy for Rousselot?
LVL: Rousselot has of course a long time experience with gelatin for pharmaceutical uses, as an excipient for example, but this is indeed our entry in the field of collagen for the health market. As Hippocrates said, “Let food be the medicine and medicine be the food”: and this is a wisdom that people are learning again, and applying using products like collagen peptides among others. More and more people desire to avoid bone disease as they age. So we are expanding our portfolio in this direction.
AF: Collagen, in the form of gelatin, is also an excipient. What challenges is Rousselot facing in this field?
Sylvie Audoly: For several reasons, different types of materials have recently entered the capsule market, such as HydroxylPropylMethylCellulose (HPMC), modified starches, or pullulan. However these materials do not offer the same features as gelatin. We felt it appropriate to provide customers with a detailed and objective comparison of the characteristics of gelatin versus HPMC, pullulan and modified starches when manufacturing hard capsules or soft gels. The comparison reviews following key factors: consumer preferences, technical aspects and operational effectiveness.
Caroline Brochard-Garnier: For example, customers often mistakenly associate vegetal origin with naturalness and could therefor prefer HPMC because it is a product of vegetal origin. But HPMC is also the result of a heavy chemical process and is classified as additive (E464) while gelatin is naturally sourced with no chemical modification and no e-number.