54 Chimica Oggi - Chemistry Today - vol. 37(2) March/April 2019 PERSONALISED MEDICINES RAJIV KHATAU LODAAT Pharma, Chicago, USA This empowerment to the patient is now occurring because the public can analyze their DNA at a reasonable cost- something that just a few years ago was unheard of. Let’s segment the tools of personalized medicine into 5 major areas. We at LODAAT have done exactly that, and we are building our products, and innovations around these sectors: 1. Gene sequencing, 2. Brain mapping, 3. Vitals tracking 4. Big Data 5. Genetic customization Once we understand personalization, we insure that data and innovation that can be tracked by these tools. It truly relies on the advancement of technology and the complexity of computers to lead the charge. On the surface, taking this approach to developing new ingredients is costly, and not time effective. However, it quickly becomes clear that personalized medicine is not only better for the patient but is also great for healthcare and pharma and eventually the ROI. In the long run, personalized medicine allows patients to be treated to their own specifications, rather than in a generalized way, which may not be effective. Imagine being able to use exactly the right amount of medication or the exact amount of health inducing assay for a patient, and thereby reducing the amount of waste and ensuring patient success. An example is with curcuminoid as a personalized supplement. First, one’s personal situation is analyzed. Then, genome sequencing adds additional information. DNA-based variations in the genes or enzymes impact different patients in a variety of ways. Knowing ahead of time, if a patient will have an adverse reaction to treatment allows doctors and consumers to make a better-informed decision on the optimal dose or treatment. The curcuminoid is analyzed using rapid separation liquid chromatography technology, and other fingerprinting technology. This step is key. Rather than assuming each pill, each plant, is perfectly uniform, it assumes there are imperfections in the system. These imperfections will exist regardless of the type of medication used. This testing allows for quality control at the end product, not at the origin. The end game is efficient and cost-efficacy across the entire healthcare system. Both the consumer, and the supplier will see the upside of this. Now let’s imagine if all this detail, the RSLC and fingerprinting technology was visible via a scanner on product packaging and this was then tied in to a DNA kit. The dosage of ingredient best matched to the consumer would then be visible, and the consumer would even know how to take the I was recently at an international biotech conference in San Francisco. Among leading venture capital, bankers, scientists, and entrepreneurs, one of the hottest topics was PERSONALIZED MEDICINE. Personalized medicine is the future. Currently, the model for Pharma companies is “will this treatment work for most patients,” and modern wellness is moving towards a model that asks “will this treatment work for this individual patient.” We are thus defining Personalized medicine as the equipping consumers with the knowledge and power to make choices into desired actions as it relates to customized individual health and wellness- the making of The Citizen Doctor. If we understand this general concept of Personalized Medicine, the next question is how does it affect the natural ingredient business, and the intersection of functional food, nutraceuticals and pharmaceuticals? As managing director of a science based pharmaceutical and botanical ingredient manufacturer, we have thought long and hard about what this term and trend means for the pharmaceutical and food- medicine industry. Let’s start with a couple of premises. First of all, major disruptors exist in every industry. Firms such as Uber, Spotify, and AirBnB are completely turning age-old industries on their heads. So, why are we unable to have major disruptors in the health and pharmaceutical space? We currently have technology advancing at such high velocity, it is easy for other industry to shift. However, health and pharmaceutical faces some unique challenges. For one, the market is highly regulated, making it slow to change. Second, there is a lack of shared data in health. Third, quality assurance is key. All these so-called roadblocks to progress are set to ensure the highest level of care and privacy for the patient. It is also important to note, that unlike other industries, government regulation is key in healthcare and pharma. Personalized medicine can assist in lowering some of these barriers. Citizen doctor: personalized medicine for ingredient industry Personalized medicine can be implemented on an ingredient level for the nutraceutical, food and beverage industry. New tools for genetic mapping strengthen the intersection between consumer product (functional food) and pharmaceutical companies, and will empower consumers/patients to take charge of their own healthcare. ABSTRACT KEYWORDS: Personalized medicine, botanical ingredients, functional food, patient empowerment, gene sequencing, vitals tracking, genetic customization, chromotography. SECTION PHARMA HORIZON Latest news on the Pharma manufacturing value chain