AGREYNIST® is an anti-free radical and pro-pigmenting active ingredient of plant origin, enabling greying hair to return to its natural color without the need of dyeing it.
AN UNPRECEDENTED ANTI-GREYING APPROACH
Greying of hair is an unavoidable phenomenon, however, there is a strong consumer expectation to avoid it with natural solutions. Faced with this observation, SILAB developed AGREYNIST®, a natural active ingredient capable of regulating the biological pathways leading to greying, in particular:
– it restores the oxidative balance of hair, a necessary factor of any anti-greying strategy, not only by reducing the formation
of free radicals, but also by activating cell detoxification induced by autophagy;
– it favors repigmentation of the hair fiber by stimulating the synthesis of melanin with its cytoprotective effect;
– it re-establishes the structural quality of hair (result from an original modeling study*).
* Using Raman microspectroscopy, SILAB conducted a more detailed analysis of the course of greying and, in a novel way, has shown that there are changes in molecular markers related to biomechanical properties (conformation of proteins) and to the barrier function (organization of lipids) in grey hair.
A REPIGMENTING EFFECT
The repigmenting effect of AGREYNIST® was demonstrated on Caucasian and Asian, male and female volunteers. Indeed, a visual scoring by experts on photos highlighted that after 4 months of daily application, AGREYNIST® formulated at 2.5% in a lotion significantly decreases the stage of greying by 20% (P < 0.001) on Caucasian volunteers, corresponding to an average decrease of one stage of greying (result visible in 91% of volunteers). A subjective evaluation confirmed these data, as after 6 months of use, 91% of the volunteers reported that they have fewer grey hairs and 88% of them considered that it is an anti-grey hair product.
TWO PLANTS WITH COMPLEMENTARY EFFICACIES
In order to address effectively the issue of hair greying, SILAB implemented a screening of natural raw materials targeting the indispensable anti-free radical and pro-pigmenting effects. This work led to the identification of two raw materials: black oat seeds (anti-oxidant and detoxifying) and spiny restharrow roots (pro-pigmenting). The use of green solvents combined with enzymatic bioengineering enabled the optimized extraction of molecules of interest. SILAB thus concentrated and stabilized in AGREYNIST® the complementary efficacies of these two raw materials obtained from a controlled supply chain. With its protective, detoxifying and repigmenting action, AGREYNIST® (INCI name: Butylene Glycol & Water & Ononis spinosa Root Extract & Avena strigosa Seed Extract) offers a natural solution for grey hair care. Composed of biopeptides and polyphenols, this patented active is available in aqueous solution (recommended amount: 0.5 to 2.5%) and compliant with international cosmetic regulations (Europe, United States, Japan, China, etc.).