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- 06/10/2020

Alternatives to animal testing continue to be widely used

Chimica Oggi-Chemistry Today

The findings of ECHA’s fourth report on the use of alternative methods to animal testing under REACH show, in general, relatively few changes in the use of alternatives since the last report in 2017.

The most common adaptation was the use of information on similar substances (read-across, 25

The amendment of the REACH annexes in 2016, that requires companies to use non-animal testing (in vitro, in chemico) for certain endpoints, has had a clear impact since their use has tripled for skin corrosion/irritation, quadrupled for serious eye damage/eye irritation and increased more than 20-fold for skin sensitisation.

Registrations for substances registered between 10-100 tonnes per year generally follow a similar pattern in terms of alternative methods and adaptations as those in higher tonnage bands. The exception to this is for acute toxicity, where there have been 3

For the lowest volume substances (between 1-10 tonnes per year), fewer experimental studies and less read-across have been observed, but this is balanced with more weight of evidence, QSAR and data-waiving.

Looking towards the future, the data collected in the REACH registration database is a good starting point for developing a unique chemicals knowledgebase that could be used to develop alternative approaches to animal testing and lend support to increasing the production and use of sustainable chemicals and the goals of the European Green Deal and the Digital Agenda.

Since many registration dossiers still need to be updated for them to be compliant with REACH, ECHA urges companies to make use of all guidance and tools at their disposal to strengthen their use of alternative approaches when reviewing and updating their registrations.

 

www.echa.europa.eu

 

 

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