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- 11/27/2023

Calisensix™, Calm your skin, enjoy your senses

HPC Today

Bright lights, loud noises, and crowded areas are just a few stressors that can overstimulate our senses. This can result in sensory overload and increased unpleasant skin sensitivity.


Sensitive skin can be defined as an unpleasant sensory response to normal stimuli that affects our self-perception. Objective irritation tests do not always detect sensitive skin so self-perception can be used as an alternative means of identification.


Calisensix™ treats sensitive skin from a holistic and innovative approach. It targets nociception in keratinocytes. Other ingredients target TRPV1 in neurons, but keratinocytes also express TRPV1 that can be sensitized by noxious stimuli resulting in the release of inflammatory mediators that induce neurogenic inflammation.


Also introduces a new player in cosmetics by boosting an endogenous TRPV1 inhibitor (resolvin D2) in keratinocytes. Moreover, it modulates the inflammatory cascade in the keratinocyte and hence the consequent nociceptors activation in the neuron (proved in a co-culture of keratinocytes and neurons).


Calisensix™ is an ingredient obtained from the bark of white willow and the stem cells from tomato coming from the Greenology technology. Calisensix™ resolves neurogenic inflammation, soothes discomfort, and enhances pleasant sensations in sensitive skin, both self-perceived and objectively detected.


Calisensix™ is your skin’s mindfulness coach that improves your self-perception. Calm your Skin, Enjoy your Senses!