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- 11/22/2021

EPO: Planoràl, healthy mouth, healthy body: the link between oral health and systemic diseases

AgroFOOD Industry Hi Tech


EPO’s new patented extract Planoràl is a unique blend of Skullcap (Scutellaria lateriflora L.) and Cistus (Cistus x incanus L.), working synergistically as an antibacterial to prevent periodontitis and restore eubiosis.


The oral cavity forms an indispensable part of the human microbiome, for its unique and diverse microflora, which includes up to approximately 1000 species of bacteria, fungi, viruses, archaea, and protozoa. In normal conditions, the oral microflora maintains symbiotic relationships, also called “eubiosis”; this natural balance can be shifted towards a pathogenic state (“dysbiosis”) due to multiple factors, such as aging, changes in diet, diseases, smoke, poor oral health, etc. In this case, pathobionts can prevail on symbionts, leading to the pathogenesis of caries and periodontitis; Porphyromonas gingivalis is a main etiological factor in periodontal diseases.

Preclinical studies have demonstrated that EPO’s new patented extract Planoràl, a unique blend of Skullcap (Scutellaria lateriflora L.) and Cistus (Cistus x incanus L.), acts as a selective antibacterial against Porphyromonas gingivalis to prevent periodontitis. Moreover, Skullcap extract contributes to the antibacterial activity of the blend against Streptococcus mutans, an acid-producing bacterium involved in the development of dental caries.

The efficacy of Planoràl is also proved by the induction of beta-defensins release, with and without the presence of inflammation.

Not too long ago, literature evidence began to suggest a link between chronic oral inflammation and some systemic diseases. In fact, periodontitis is a constant potential source of infection and inflammation, and it has been considered a risk factor for cardiovascular, cerebrovascular, and respiratory diseases, as well as a potential risk for increased morbidity and mortality for diabetes, insulin resistance, rheumatoid arthritis, obesity, osteoporosis and complications of pregnancy.

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