Pierfrancesco Morganti
R&D Center, Nanotechnology Unit, Academy of History of Healthcare Art, Rome, Italy
Dermatology Department, Regional Hospital, China Medical University, Shenyang
Abstract
Nanotechnology (Nc) and Nanobiotechnology (Nb) represent novel promising industrial technologies, rapidly increasing year by year. Nc is an industrial field where chemistry, phisics and engineering interact with nanostructured materials, while biology and medicine are enclosed in Nb also. Thus, functionalized molecules are used, for example to make nanochips as well as biomolecules and innovative drugs in medicine, food and Cosmetics to ameliorate and increase the actives’ transepidermal and transdermal delivery across skin and mucous membranes’ barriers. Examples of some studies on these topics where reported from the Conferences taken in Rome on Advanced Nanomaterials and Nanotechnology and from the International and Chinese Dermatology Society.
Introduction
The use of Nanomaterials in the field of Nanotechnology represents a quick advancement in many industrial sectors, such as electronic, telecommunications and agriculture, as well as Medical, Cosmetic and food engineering. Just to remember, nanomaterials are very tiny particles with a size comprised between 1 and 100 Nanometers (nm).One nm has a length equal to a billionth of a meter, the human hair is approximately 80,000-100,000nm wide, while the red blood cell 7000 nm and a strand of DNA 2.5nm wide. Thus the necessity to control the nanoparticles by specialized tools, being not visible by the eyes.
International Conference – Advanced Nanomaterials and Nanotechnology
At this purpose, many were the topics reported by the International Conference –Advanced Nanomaterials and Nanotechnology-held in Rome in two days (June 12-13 2025) organized by Scisynopsis LLC from Atlanta USA.
First day
Associated Professor Ali Al-Samydai, from Ahliyya University of Amman (Jordan) opened the first session, reporting and discussing a meta-analysis useful to control the stability of advanced drug delivery system for different phytosome compounds [1].By its study it was concluded that the use of phytosomes at their nanosize are revolutionizing drug delivery systems representing innovative approaches in cancer treatments.
Soon after professor Mohammed Saad Al-Ghamdi reported examples of electrical investigations in semiconductor laser diode structures showing that the single quantum device seems able to well reflect a greater susceptibility to thermal excitation and carrier leakage, while the triple quantum ones maintains a higher barrier height throughout the temperature range, supporting a better carrier confinement and a reduced barrier leakage.
Prof. Mark R Hoffman and Patrick K Tumukong from University of North Dakota, USA, have reported and amply discussed the low-Lying electronic state of the Nickel dimer, seeming to be the exact symmetry of its ground state, is still debated.
Valery Ligatchev from Singapore showed and discussed the thermal expansion and specific heat capacity of nano-structured lattice controlled by the MIT Technique. This topic is of great interest for the aerospace Industry that has necessity to know its specific heat capacity with the relative thermodynamic and phase equilibria at high temperature of the material used.
Dr Qi,Chen and Zhou from Cardiff University (UK) and Institute of Mechanics and Medical Engineering Tsighua Uiversity, China have shown that brick–and-mortar structure of both skin and natural nacre offer powerful frameworks for developing Advanced Nanomaterials with exceptional mechanical properties. These structures are suitable for making graphene nanosheets as well as biocompatible films and tissues for cosmeceutical and nutraceutical applications, something I have also observed in my personal experience. It is interesting to underline that nanodimension results of great utility not only in the mechanical and electronic fields but also in medicine, Cosmetic and food sectors, because of the possibility to realize biomimetic/biocompatible structure/ingredients for skin and other human organs, able to easily overcross their respective barriers. Climate waste as well as air pollution are creating serious problems for Environment and human health. These the topics reported from Larue and Belbekhouche of East Paris Institute of Chemistry and Material Science University and Al-Hassani and Colleagues from Al-Karik University of Environmental Science in Iraq, showing respectively the promising anticancer activity of nanostructured lipid carriers and the waste-lead and heavy metals adsorption’ capacity, evidenced by the azolla pinnata-nanoparticles.
Second day
There is an urgent need to develop new research studies and technologies for developing and producing thinner microchips as well as
determining in real time the early signs of diseases at the Cellular level by electron beam and deep ultraviolet lithography and nanophotonic tools respectively. Of particular interest the nanomedicine sector by molecule type with a global market of USD 139 billion in 2022 and expected to grow at a Compound Annual Grow Rate(CAGR) of 10.2percent from 2023 and 2032(figure 1) while the nanochips market was USD 8 billion in 2024 with a CAGR of 12percent during the forecast period 2025-2033(figure 2)
Figure 1. Global Nanomedicine market (Courtesy of Sil market .us[2]
Figure 2 Global Nanochip market (Courtesy of Sfraits [3 ]
The levofloxacin-functionalized by gold-nanoparticles was the topic reported by Hany Akeel Al-Hussaniy from Al-Nisour University College in Irak. The scientist showed the higher effectiveness of this new antibiotic compound, while from the same University, prof Jasim Mohammed Salman discussed an interesting methodology used to adsorb heavy metals from water by the plant Ceratophyllum Demersum activated by Carbon nanoparticles. On the other hand,professor Newaz Mohammed Bahadur from Noakhali Science and Technology University in Bangladesh, reported a novel synthesis of pure and doped-hydroxyapatite nanocomposite, useful for the photocatalytic degradation of amoxicillin and ciprofloxacin.
Many other papers were presented at the 4th International Conference on Advanced Nanomaterials, where the crucial role of Nanotechnology and Nanobiotechnology for a more global progress was repeatedly emphasized and discussed by all participants.These two fundamental scientific disciplines are also showing a broad potential in nanomedicine, solving many disease-problems because of their significant advancement across material science, physics chemistry, biology and medicine [4].
14th International Congress of Dermatology
From June 18 to 21, the 14th International Congress of Dermatology was held in conjunction with the Congress of the Chinese Society of Dermatology (CSD). The event took place under the presidency of Prof. Xingua Gao, President of the CSD and Head of the Dermatology Department at the Regional Hospital, China Medical University, Shenyan (figure 3)[5]
Figure 3 The Chinese dermatologists at the Congress where prof Pierfrancesco Morganti and Marco Stoller were invited as hosts (in the Middle on the right and left of prof Gao respectively (Courtesy of prof Gao [5])
During this meeting, different topic regarding skin diseases were reported and discussed by many dermatologists coming directly from China.
Many dermatologists reported that the majority of the drugs and carriers they use are composed of active ingredients and delivery systems at the nanoscale [4]. In conclusion, the meetings highlighted recent advances in the synthesis and production of nanostructured materials, nanotechnologies, and nanobiotechnologies, with discussions focusing on their latest achievements in both scientific and industrial medical fields.
Conclusive remarks
As previously reported, nanotechnology is a highly interdisciplinary field representing the convergence of physics, chemistry, and engineering, while nanobiotechnology combines these principles with biotechnological disciplines. As a result, nanobiotechnology holds the potential to overcome side effects associated with conventional therapies by enhancing, for example, the efficiency of drug delivery, environmental remediation (e.g., water and soil), and enzymatic processes. It is therefore applied across four major sectors: medicine, industry, agriculture, and the environment.
In response to growing demand for skin- and environmentally-friendly products, the cosmeceutical and nutraceutical markets are expanding annually, with global compound annual growth rates (CAGR) of 3.9percent and 7.6percent, respectively (Figure 4) [7,8], partially driven by EU regulations on nanocosmetics [9–11]. Consequently, the use of active ingredients and carriers at the micro-dimension scale is increasing across medicine, cosmeceuticals, and nutraceuticals, involving particles up to 1000 nm in size [9].
For instance, microparticles of active ingredients and carriers—used as components of tissue delivery systems—have demonstrated an ability to cross both skin and mucosal barriers more effectively than traditional emulsions. These systems do not fall under the scope of EU cosmetic regulations on nanomaterials and may also reduce the risk of side effects [12,13].
Furthermore, advances in nanotechnology and nanobiotechnology, combined with nano-computing and artificial intelligence (AI), are enhancing our ability to understand the behavior of materials at the nanoscale. Parameters such as size, shape, and surface chemistry are increasingly recognized as fundamental for the development of innovative products and tools in the medical field [14–16].
In conclusion, ”the governance of Nanotechnology development for societal benefit is a challenge with many facets ranging from fostering research and innovation to addressing ethical concerns and long-term human development assessment” [17].
REFERENCES AND NOTES
1. Proceeding of Advanced Nanomaterials and Nanotechnolgy, Rome May 12,13,2025
2. Isil, Global Nanomedicine market,ISIL,New York,USA
3. Global Nanochip Market ,STRAITS Co,USA
4. Pan J,Qian H,Sun Y ,Miao Y,Zhang J and Li H. Microbially synthesized Nanomaterials: Advanced and applications in medicine. ScienceDirect 2025; doi:10.1016/j.preme.2025.100019
5. Proceeding of Chinese Society of Dermatology,Rome May 18,2025
6. Shahcheraghi N,Golchin H,Sadri Z,Tabari Y,Borhanifar F and Makani S. Nano-biotechnology ,an applicable approach for Sustainable future,3 Biotech 2022,12(3),65;doi:10.1007/ s3205-021-93108-9
7. GVR Globsl Cosmeceutical Market,side,share and trends,Gran View Research,2024(Accessed May 25,2025:
8. GVR Global Nutraceuticals Market,side,share and trends ,Gfsn View Research 2024(Accessed May 25,2025)
9. Landowski LM,Nidgo B,Sutherland BA,Hagemeyer CE,Howells DW. Applications of Nanotechnology in the diagnosis and therapy of stroke,Semin Thromb Hemost 2020,46(5),592-605;doi:10.1055/s-0039-3399568
10. EU regulation 2024/858 on nanoproducts as modification of CE 1223/2009 and 26 further addendum on the use of Cosmetic products
11. Morganti P and Paglialunga S.EU birderline Cosmetic products: review of current regulatoty status,Clinics in Dermatology.2008,26(4),392-397
12. Ghasemiyeh P. Potential of nanoparticles as permeation enhancer and targeted delivery option for skin:advantages and disadvanged.Drug Design Develop Ther 2020,14,3271-3289;doi:10.2147/DDDT.S264648
13. Morganti P,Fabrizi G,Coltelli MB,Danti S,Azimi B,Gagliardini A,Chen H-D and Morganti G. Skin delivery and innovative carrier’s effectiveness ,J Inter Med Res & Rep 2024,3(3),1-5 ISSM 2751-669
14. Menichetti A,Mordini D and. Montalti M. Penetration of microplastics and nanoparticles through skin:effects of size,shape and surface chemistry. J Xenobiot 2025,15,6;doi:10.330/jox15010006
15. Das KP and Chandra J. Nanoparticles and convergence of Artificial intelligence for targeted drug delivery for cancer therapy: current progress and challenges.Front Med Technol 2023,4,1067144;doi: 10.3389/fmedt.2022.1067144
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17. Value4nano .Industrial valorisation of strategic value chains for nano-enabled products,Seventh Framework Programme,Brant Agreement No 608684, 2013. www.cordis.europa.eu
