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- 04/15/2019

SENN – Peptides for pharmaceutical and cosmetic industry

Chimica Oggi-Chemistry Today

As a pioneer in amino acid building block synthesis, Senn Chemicals, located in Dielsdorf, Switzerland, is an established CDMO for more than 50 years. Senn Chemicals offers extensive experience and knowledge in peptide chemistry, amino acid building blocks, small molecules, complex organic molecules as well as functionalized polymers.

Peptides are of vital importance to many processes in living systems. For example, the cyclic peptide hormone vasopressin (9 amino acids), produced in the hypothalamus, is an important regulator of the body’s fluid balance.

The increasing knowledge about the action of naturally-occurring peptides (including vasopressin) is continuously applied to develop novel peptide-based pharmaceuticals, for example, for the treatment of metabolic diseases. When compared to traditional small molecule drugs, pharmaceutical peptides are considered to be safer for application in vivo as a result of their natural origin and their non-toxic metabolites (amino acids). In addition, they usually comprise considerably higher target specificities. A particular group of peptide therapeutics are peptide vaccines, which are being investigated as safer and more stable alternatives to conventional vaccines. Another group of therapeutic peptides involves antimicrobial peptides (AMPs), or host defense peptides (HDPs), which have recently emerged as potential alternatives to antibiotics. Moreover, AMPs are also considered an alternative to conventional food preservatives in food industry, an example for which is the polycyclic peptide nisin.

Due to the increasing demand for anti-aging products, peptides have also emerged as potential cosmetic ingredients. Cosmetic peptides have different modes of actions and, as for pharmaceutical peptides, their origin often lies in living systems. For example, the dipeptide carnosine, consisting of beta-alanine and histidine, functions as a scavenger of reactive oxidative species in muscles. Therefore, it is considered a potential compound to prevent oxidative stress in the skin, a major factor leading to skin aging. Another example of peptide-based cosmetics involves peptides derived from the natural fibrous protein elastin that support fibroblast growth and are therefore intended to slow the aging process of the skin.

SENN’s refined solid- and liquid-phase technologies allow for production of a wide variety of high-quality peptide related products for pharmaceutical and cosmetic applications, while routinely precluding the need for traditional chromatographic purification techniques, thereby saving costs and time.

For more information, visit Senn’s new website www.sennchem.com

Senn Chemicals – your CDMO for SWISS quality peptides and amino acid derivatives



 

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