1,1,3,3-tetramethyldisiloxane: a versatile reducing agent
Some recent applications of several highly useful reducing capabilities of tetramethyldisiloxane, TMDS, are reviewed.
The hydride of organosilanes has been employed in the reductions of a vast array of organic substrates oftentimes with excellent chemoselectivity. This high degree of chemoselectivity can be credited to the weakly hydridic character of the Si-H bond along with the large variation in catalytic protocols available to carry out the reductions. A comprehensive review of the ionic and transition metal-catalyzed silane reductions has been published (1). In addition to the potential for high selectivity via the weakly hydridic silanes the organosilane reducing agents are available in a variety of forms including the popular and easily handled triethylsilane, the more sterically demanding triisopropylsilane, the specialty phenylsilane, and, finally, the mor