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    Highlights on recent peptide achievements
  4. AN INTRODUCTION: Highlig...
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AN INTRODUCTION:
Highlights on recent peptide achievements

BRUCE H. MORIMOTO

Executive Director, Applied Translational Medicine,
Celerion, Inc., USA

ABSTRACT: Over 115 years have passed since Emil Fischer synthesized glycylglycine, a dipeptide (1), and it has been more than 50 years since Bruce Merrifield’s Nobel Prize winning paper was published on solid-phase synthesis of peptides (2). Progress in developing peptide therapeutics requires continuous innovation in multiple areas, including basic research discoveries, development of novel chemistries, and improvements in manufacturing. This issue contains articles on the recent achievements in peptides through the eyes of several industry leaders.
KEYWORDS: Peptide therapeutics, cell-penetrating peptides, stapled peptides, drug delivery, scale-up peptide manufacturing.

BIGGER AND MORE
Solid-phase synthesis revolutionized peptide chemistry and allowed for longer peptides to be made (3).  However, to make more complex and biologically active molecules, ligation chemistry enabled peptides to be linked together.   In this issue, Dr Michael Pennington, Peptides International and Daniel Bourgin from Dr Reddy’s write about the need to develop and refine ...
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AN INTRODUCTION:
Highlights on recent peptide achievements
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