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Glycosylation as a tool for improving tissue penetration of peptide-based drug leads

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SENN

With the discovery of a number of therapeutically important and promising native peptides and protein fragments, the clinical development of peptide and peptidomimetics drug leads has become a priority of academia as well as the pharmaceutical industry. This expanding family of drug leads still has important restraints towards clinical use due to the physicochemical properties of most bioactive peptides. The increased size and faster degradation compared to traditional non-peptidic drugs only partiall