The skin hosts a diverse microbial community that supports barrier integrity, immune balance, and overall cutaneous health. This ecosystem—dominated by Staphylococcus, Cutibacterium, and Corynebacterium—varies by local skin conditions and provides protection against pathogens. Intrinsic and extrinsic factors such as aging, pollution, and cosmetic habits can disrupt this balance, leading to dysbiosis and impaired skin function. This review, recently published in cosmetics, highlights how age-related microbial shifts may contribute to inflammation and visible skin aging.
Here you can find the abstract of the paper:
Background/Objective: The skin microbiome plays a pivotal role in barrier function, immune regulation, and overall skin health. Age-related changes and environmental stressors disrupt microbial homeostasis, contributing to inflammaging and esthetic concerns. This narrative review aims to explore the potential interactions between the Hydro Deluxe Skin Booster and the cutaneous microbiome, with emphasis on barrier integrity, hydration, and molecular pathways relevant to skin aging. Methods: A literature search was performed in PubMed and Scopus up to September 2025. Keywords included skin microbiome, cutaneous dysbiosis, hyaluronic acid (HA), calcium hydroxyapatite (CaHA), amino acids, skin boosters, skin aging, barrier function, and inflammation. Eligible articles included in vitro ex vivo, and clinical studies addressing microbiome-related mechanisms in skin health and esthetic interventions. Results: The literature indicates that HA and skin boosters enhance hydration and reduce transepidermal water loss (TEWL), indirectly supporting microbial balance. Aging is associated with sebaceous decline, altered pH, reduced levels of commensals (Cutibacterium acnes, Staphylococcus epidermidis), and increased opportunists (Streptococcus, Staphylococcus aureus). Hydro Deluxe, a formulation combining HA, CaHA, and amino acids, may synergistically stabilize the cutaneous environment by restoring hydration, reducing inflammatory mediators, and promoting dermal remodeling. Current evidence, however, is largely limited to in vitro and ex vivo data. Conclusions: Hydro Deluxe appears to be a promising esthetic intervention with potential to support cutaneous microbial homeostasis and mitigate age-associated inflammatory changes. Further well-designed clinical trials are warranted to validate its microbiome-related effects and to clarify its role in evidence-based esthetic medicine.
