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- 06/12/2017

ALGOPHAGYL®: Protect the mitochondrion for revitalized skin

H&PC Today

ALGOPHAGYL® is a natural energizing active ingredient capable of preserving the equilibrium and correct functioning of mitochondria to bring skin radiance and vitality back.


Activation of three mitochondrial defense levers

The mitochondrion is the only generator of cellular energy. Chronic or acute stress can cause its dysfunction, which then gives rise to harmful effects on the skin.

SILAB offers ALGOPHAGYL®, an innovative active ingredient activating three defense levers:

  • the quality control of mitochondria;
  • the mitochondrial dynamics*;
  • the mitophagy

When healthy, mitochondria produce the necessary energy for cell regeneration [1] and for establishing a dynamic and effective skin barrier.

*SILAB specifically developed the MITOSHAPE® technology. This novel tool enables the automatic quantification of the processes of mitochondrial fission and fusion and results have been published: Jugé et al., Quantification and Characterization of UVB-Induced Mitochondrial Fragmentation in Normal Primary Human Keratinocytes. Scientific Reports, 6, 1-9 (2016). 

[1] In comparison to the placebo and as of two hours after a single application, ALGOPHAGYL® significantly stimulates the production of ATP by +51.1%. This effect continues after 7 days of twice daily applications (+54.2%).


Improvement of skin quality

After 28 days of twice daily applications and in comparison to   the placebo, ALGOPHAGYL® lightens the skin of Caucasian and Asian volunteers, with a significant increase of parameters L* and ITA°, characteristic of lighter and more luminous skin.

In addition to lightening the skin, ALGOPHAGYL® restores the complexion radiance. After 14 days of twice daily applications and in comparison to the placebo, ALGOPHAGYL® formulated at 2% in an emulsion:


  • increases the skin reflection by 5.3%;
  •  restores a fresh complexion (pink color) by 7.7%
  • decreases the olive color by 6.1%
  • attenuates the state of eye fatigue by 7.1%.

This effect continues after 28 days. A subjective evaluation by the volunteers confirms these data: 100% of them report that their skin is revitalized, more luminous and suppler.


An inexhaustible richness in diversified active molecules

Because microalgae are the basis of life, SILAB’s Research is focusing on their metabolic and adaptogenic properties in order to ensure the protection of the mitochondrion.

Rich in glucans and galactans, ALGOPHAGYL® (INCI name: Chlorella sorokiniana Extract) is obtained from the microalga Chlorella sorokiniana, industrially manufactured in SILAB biotechnologies production unit. The heterotrophic culture of this microalga, which means grown in darkness, obliges it to synthetize molecules of specific interest with high added value. 

Obtained from a non-denaturing manufacturing process, ALGOPHAGYL® is a patented active ingredient, available in aqueous solution (recommended amount: 0.5 to 2%), and compliant with the main cosmetic regulations (Europe, United States, Japan).


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