Print this article
- 03/20/2023

Discover a new Alteromonas species for a vertical development of a novel active ingredient

HPC Today

Tags:

 

There is innovation in the mechanism of action, in the origin of the active ingredients and even in the technology used to obtain them. But, what if we discover a new microorganism?

LipoTrue S.L. presents a total vertical integrated product, fully controlling the three key steps: discover, develop and deliver. An innovative vertical approach for an ingredient obtained from a new identified Alteromonas strain: Alteromonas lipotrueae.

This microorganism was found living in symbiosis on the surface of the most stinging jellyfish in the Mediterranean Sea, the Pelagia noctiluca. The metabolomic analysis of the bacterial extract that secrets confirmed that it contains several compounds involved in muscle contraction that may help them to protect itself from the jellyfish neurotoxins.

V/WA™ is the active ingredient obtained from the fermentation of Alteromonas lipotrueae. The compounds produced and secreted by Alteromonas lipotrueae allow it to cope with the stinging compounds of this jellyfish, has shown to modulate neuritogenesis, and the development of the neuromuscular junctions helping to relax expression lines.

A novel approach in the field of the botulinum-like ingredients, that allows the total vertical integration of a product from the discovery through the development to the delivery.

It is the first vertical integrated product in the cosmetic market, since Lipotrue controls and has the ownership of all the steps of the process: from the identification of a new strain to the development and delivery of a novel active ingredient to the cosmetic manufacturers.

Moreover, V/WA™ approaches expression wrinkles mechanism from another point of view. It is able to modulate neuritogenesis and so the formation of synapsis between neurons and muscles. It also modulates clathrin, which coats the synaptic vesicles. Synaptic vesicles recycle once fused with the basal membrane to ensure a quicker reload and release of the neurotransmitter. Hence, by regulating clathrin, this vesicle recycling is slowed and thus there are less vesicles ready to release neurotransmitters and induce contraction. In addition, it has also proved to be efficient in modulating the post-synaptic pathway.

The fact of having the ownership of all the steps, allow us to have a complete knowledge and control of the ingredient.

 

Discover V/WA™ at www.lipotrue.com