Isorhamnetin is an emerging multifunctional bioactive compound that represents a new generation of botanical solutions for oily and blemish-prone skin.
Extracted from Opuntia ficus-indica (prickly pear) flowers, it is the key active component of PURYFLOWER™, a natural ingredient developed by Bionap to rebalance the skin ecosystem through a multitarget mechanism of action.
Pre-clinical data demonstrate that isorhamnetin acts at the biological root of oily skin, inhibiting 5-α-reductase expression, reducing oxidative stress, and limiting sebocyte over-proliferation. These combined activities help control excessive sebum secretion while preserving the skin barrier and microbiome equilibrium.
The efficacy of isorhamnetin-rich PURYFLOWER™ was further confirmed by a randomized, double-blind clinical trial on 22 volunteers with combination to oily skin.
After 14 and 28 days of use, results showed:
- Sebum content reduction up to 21.1 per cent;
- mattifying effect lasting up to 7.1 hours;
- Sebum excretion rate (SER) decreased by 35 per cent;
- Pore size reduction up to 26 per cent;
- TNF-α levels reduced by 7.4 per cent.
In addition, microbiome and lipidomic analyses revealed that the ingredient maintains microbial diversity while promoting the growth of beneficial species such as Staphylococcus epidermidis and Lactobacillus spp..
At the same time, it enhances the skin’s lipid profile, increasing ceramides and triacylglycerols responsible for hydration and barrier integrity.
Sustainably sourced and COSMOS-approved, PURYFLOWER™ offers formulators a biomimetic, microbiome-friendly solution compatible with both hot and cold processes. Its versatility makes it suitable for creams, gels, toners, and make-up formulations designed to purify and mattify the skin without compromising comfort.
With isorhamnetin as its scientific core, PURYFLOWER™ embodies the Mediterranean innovation that defines Bionap’s commitment to effective, natural, and sustainable cosmetic actives.
