Preclinical evidence highlights the remarkable potential of Pomanox® pomegranate extract to promote healthy aging and longevity. Obtained from polyphenol-rich fresh pomegranate fruit and gently processed with water as the only solvent, Pomanox® positively influences the aryl hydrocarbon receptor (AHR) pathway – a critical regulator of detoxification, inflammation and cellular balance.
In a landmark study recently published in the International Journal of Molecular Sciences (1), researchers found that centenarians – those over 100 years old – had significantly higher AHR gene expression than younger people. This increased AHR activity suggests a protective mechanism in centenarians that aids in detoxification, reduces oxidative stress, and maintains cellular balance.
In C. elegans, a model organism for aging studies, pomegranate extract not only extended lifespan but also improved vitality. By activating the AHR, Pomanox® reduced oxidative damage and promoted a healthier, more active aging process.
Parallel research in mice showed that Pomanox® supplementation modulated the AHR pathway in the liver, a key organ for detoxifying harmful compounds. This modulation highlights how Pomanox® could enhance the body’s detoxification processes, thereby supporting overall health and longevity.
Further supporting these results, another study found that Pomanox® reduced the adverse effects of high fructose consumption in mice. It reduced weight gain, hepatic steatosis and dyslipidemia, while improving metabolic profiles, reducing inflammation and positively influencing the gut microbiota, suggesting its potential to prevent age-related metabolic decline while improving liver health (2).
Complementing these findings, a study in Antioxidants (3) showed that Pomanox® improved motor coordination, reduced oxidative stress in the cerebellum, and reversed age-related brain markers in older mice. These results highlight its potential to prevent age-related decline.
Preclinical evidence is consistent with clinical findings where Pomanox® has shown multiple benefits, including athletic performance, cognitive function, cardiovascular health and skin beauty (4-6). The antioxidant-rich polyphenols help fight oxidative stress, improving endurance, mental clarity, heart function and skin health.
Taken together, these findings demonstrate the comprehensive benefits of Pomanox®, from cellular detoxification to metabolic protection, providing a holistic approach to aging well. Whether improving athletic performance, cardiovascular health or skin vitality, Pomanox® offers a scientifically backed solution for healthy aging.
References:
1 – Serna, E. et al. Int. J. Mol. Sci. 2024, 25(18), 9943; https://doi.org/10.3390/ijms25189943
2 – Sánchez-Terrón R, et al. Food Funct., 2024; https://doi.org/10.1039/D4FO00688G
3 – Verdú, D. et al. Antioxidants 2023, 12, 1991; https://doi.org/10.3390/antiox12111991
4 – Al-Dujaili, E.A. et al. Antioxidants, 2022, 11(11), 2124; https://doi.org/10.3390/antiox11112124
5 – Torregrosa-García, A. et al. Nutrients, 2019, 11(4), 721; https://doi.org/10.3390/nu11040721
6 – Stockton, A. et al. Brain Health and Beyond, AP 2021 https://doi.org/10.1016/B978-0-12-820593-8.00010-0