Angelini – Flow chemistry as novel chirotechnologic tool for asymmetric synthesis of apis


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The issue of drug chirality is now a top-class subject in the discovery and development of NCEs, underpinned by a new understanding of the role of molecular recognition in many pharmacologically relevant events. The application of chiral drugs implies obvious benefits as concerns therapeutic, toxic, and pharmacokinetic effects, while in many cases it also enables the administration of lower dosages as compared with the corresponding racemic substances. Additionally, when therapeutic activity is associated with only one enantiomer, the gratuitous existence of the ineffective isomers is a direct source for various environmental burdens; for example, concerning the environmental fate and ecotoxicity of the substances involved. Nevertheless, a large number of chiral drugs hav ... ...