P. 48-52 /

Application of Pyridoxine 3,4’-cyclic phosphate for pore size and facial shine reduction – Attractive functions of Pyridoxine 3,4’-cyclic phosphate: Stable form of Pyridoxine (Vitamin B6)


1. Kyowa Hakko Europe GmbH, Am Wehrhahn 50, Düsseldorf, D-40211, Germany
2. Daiichi Fine Chemical Co., Ltd., 530 Chokeiji, Takaoka, Toyama, 933-8511, Japan
*Corresponding author


Formulators all over the world have been facing a challenge when formulating with Vitamin B6 such as Pyridoxine due to its poor light stability and formulating difficulty. We have developed Pyridoxine 3,4’-cyclic phosphate (PanadoxineTM P), a Vitamin B6 derivative with a superior stability especially in sunlight. In a clinical study carried out over the course of 4 weeks the application of Panadoxine P gave a significant reduction in pore size and facial shine. In-vitro studies showed that Panadoxine P inhibited 5α -reductase and suppressed also secretion of IL-6 and IL-8 from human skin keratinocyte when exposed to UV-B rays. The results of these tests make Panadoxine P to be considered as a useful ingredient for oily and sensitive skin (1).

Skin care for a beautiful and healthy skin is an eternal theme. Especially in recent years the interest in this field has increased significantly, regardless of gender.
Vitamin B6 such as Pyridoxine is well known as a vitamin for skin health and widely used for drugs, food additives and feed additives. However and due to the fact that Pyridoxine is not stable in light (2, 3), it has not been widely used for cosmetics.
To improve the light stability of Pyridoxine, we focused our examination on the protection of the OH-group at position 3 since the cleavage of the O-H bond was considered as the initial reaction of photo degradation. We therefore synthesized several derivatives according to this concept. Lastly we developed Panadoxine P (INCI name: Pyridoxine Cyclic Phosphate, Chemical name: Pyridoxine 3,4’-cyclic phosphate): Figure 1.
Panadoxine P is very stable in light and heat and easy to dissolve in water and solvents such as Ethanol, Glycerin, Propylene Glycol and 1,3-Butylene Glycol (4). Panadoxine P is not only the stable form of Pyridoxine but also has some properties to inhibit 5 -reductase and IL-6 and IL-8 ...