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Catalytic C-C coupling reactions From Discovery to Nobel Prizes and industrial applications

HANS-ULRICH BLASER*, BENOÎT PUGIN, DIRK SPIELVOGEL
*Corresponding authorSolvias AG, Römerweg, Kaiseraugst, CH-4002, Switzerland

Abstract

After a short description of the achievements of thethree Nobel laureates, R&D issues for the application ofPd coupling reactions in the fine chemicals industry arediscussed. In a first part, some background is given onindustrial R&D and the role of coupling for preparativeapplications is described. Thematic approaches toindustrial R&D are described and two of these are illustratedwith relevant examples from the literature and from ourown laboratories: i) Development of catalytic systems withvery high turnover numbers; ii) Catalysts and ligands forcoupling reactions with aryl chlorides. Finally, four selectedPd catalyzed production processes are briefly described.


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