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Cyclodextrins for life cycle sweat malodor control “mixture of natural cyclodextrins in deodorants for malodors control of humans of different ages and sex”

corresponding

NUNZIO DENORA2, DANIELA DONELLI1*, GIANFRANCESCO INNOCENTE1, ELISA LIBERATI1, LORELLA RAGNI1, VINCENZO RUSSO1, SERENA TONGIANI1
*Corresponding author
1. Angelini S.p.A, Pomezia, Italy.
2. Department of Pharmacy, Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy 

Abstract

Cyclodextrins are a class of cosmetic ingredients useful to control body malodor, since they are able to complex molecules responsible of unpleasant smell. They have an internal hydrophobic cavity able to include different malodorant organic compounds, as well as a variety of fragrances. Upon deodorant wetting by sweat, cyclodextrins exert a dual action: they capture malodorant molecules and release a complexed fragrance. Since, recent studies have shown that body odor carries age-related and gender-related information. The aim of this work was to identify some representative molecules, responsible to cause body malodor, during the perspiration of humans of different ages and sex, and to develop a new technology, based on different mixtures of natural cyclodextrins, able to capture these specific molecules.


STATE OF THE ART

Body malodor is a perceived unpleasant smell our bodies can give off when bacteria that live on the skin break down sweat into acids, some say it is the smell of bacteria growing on the body, but it really is the result of bacteria breaking down protein into certain acids. Sweat itself is virtually odorless to humans; it is the rapid multiplication of bacteria in the presence of sweat and what they do (break sweat down into acids) that eventually causes the unpleasant smell. (1) The human skin is naturally populated with numerous microorganisms which are nourished by various skin secreted substances (eccrine and apocrine sweat, and sebum), skin cell debris, breakdown products of the skin and the organisms themselves. These unpleasant body malodors are mainly organic molecules which have different structures and functional groups, such as amines, acids, alcohols, aldehydes, ketones, phenols, indoles, aromatics, polyaromatics, and so on. They can also be made up of sulphur containing functional groups, such as, thiol, sulfide and/or disulfide groups. 

 

Active ingredients in malodour control:

Numerous attempts ha ...




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