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Glucose lowering activity of Coprinus comatus

BO LI1*, FEI LU1, XIAO-MIN SUO2,1
*Corresponding author
1. School of Food Science, Henan Institute of Science and Technology, Xinxiang, 453003, China
2. School of Food Science, Huazhong Agricultural University, Wuhan, 430070, China

Abstract

The glucose lowering activities of five extracts from the stipe of Caprinus comatus were studied, as were the fruitbodies of C. comatus – separated into stipe and cap, then dried and milled to obtain stipe powder and cap powder.Ethanol extract, water-soluble polysaccharide, alkali-soluble polysaccharide, protein and crude fibre were extracted fromstipe powder, and their glucose lowering activities were investigated in alloxan-induced diabetic mice. The sevenexperimental groups were given an extract, stipe powder or cap powder (300 mg/kg po daily) for 28 days. The resultsshowed that water-soluble polysaccharide presented the best glucose lowering activity in five extracts and it can almostdecrease the blood glucose of diabetic mice to a level of normal mice after 28 days. Cap powder was most effective withglucose lowering activity, for its efficacy was evident within 7 days. Therefore, water-soluble polysaccharide of stipe or thecap powder of C. comatus can be developed as potential oral hypoglycemic agents or functional foods in the control ofdiabetes mellitus.


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