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Granisetron potentiometric sensor based on computational study 

MOHAMMAD REZA GANJALI1,2*, FOROUZAN ABOUFAZELI1, FARNOUSH FARIDBOD2, SIAVASH RIAHI1,3, PARVIZ NOROUZI2,1
*Corresponding author
1. University of Tehran, Center of Excellence in Electrochemistry, Faculty of Chemistry, Tehran, Iran
2. Tehran University of Medical Sciences, Endocrinology and Metabolism research Centre, Tehran, Iran
3. University of Tehran, Institute of Petroleum Engineering, Faculty of Engineering, Tehran, Iran

Abstract

Granisetron (GRN) prevent the nausea and vomiting that may occur after treatment with anticancer medicines in chemotherapy or radiation therapy. In this study, a potentiometric liquid membrane sensor for simple and fast quantification of granisetron hydrochloride in pharmaceutical formulation and urine was made. Based on some theoretical calculations, GRN-tetraphenylborate ion pair was selected as a sensing material in the organic phase of the PVC membrane. The wide linear range (10-5-10-2 mol L-1), low detection limit (7.8.10-6 mol L-1), and fast response time (~35 s) are the characterizations of this electrochemical sensor. Validation of the method confirms suitability of the sensor for use in the quality control analysis of granisetron hydrochloride in pharmaceutical formulation.


 

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