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Molecules of the future with high demands on purity
Therapeutic oligonucleotides and peptides are biopolymers with enormous potential. The reliable and safe production of these molecules is a challenging task because of the impurity profile and the high demands on purity and structural integrity.

For the purification of these types of molecules, (ion-pair-) reversed phase (RP) chromatography is a powerful technique that allows high purity levels with increased productivity. With this technique, efficient separation of small chemical and structural variants is possible – e.g. the separation of single nucleotide differences in oligonucleotides. For a robust and productive purification process, innovative, robust and reproducible stationary phases are needed. The selection of the most appropriate RP phase is t ...