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Long Peptides and Multiple Scales on the Overture™ Robotic Peptide Library Synthesizer

CHRISTINA A. CHANTELL*, MICHAEL ONAIYEKAN, JAMES P. CAIN, OGAGA OJAMERUAYE, MAHENDRA MENAKURU
*Corresponding author
Protein Technologies, Inc. 4675 S. Coach Dr. Tucson, AZ 85714 U.S.A.

Abstract

The Overture™ is the first robotic peptide library synthesizer that cansynthesize multiple scales in the same synthesis. In addition, it canalso synthesize high purity peptides greater than 15-20 amino acidsin length. In this article, the 65-74 fragment of the acyl carrier protein(65-74ACP) was synthesized on the Overture™ at the 5 and 20 mmolscales simultaneously, and the 31-mer C-peptide was synthesized onthe Overture™ with similar crude purity as the non-robotic Symphony®.


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