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P. 30-34 /

Potential control in calories intake and prolonged satiety effect promoted by apple polyphenols


*Corresponding author
1. Principium SA, Via Luganetto 4, 6962 Viganello (TI), Switzerland.
2. Farcoderm srl, Via Mons. Angelini 21, 27028 S. Martino Siccomario (PV), Italy.
3. University of Calabria, Dept. of Pharmacy, Health and Nutritional Sciences , 87036 Rende (CS), Italy.


Growing evidence is rising about the potential of a conscious and responsible nutrition to promote health and reduce cardiovascular risk. Weight management and healthy life-style are the primary approach. The current article provides the scientific rational for the use of dietary supplementation based on standardized apple polyphenols to control of calories intake by reducing sugars and carbohydrates absorption.
In vitro data are reported, showing the superior antioxidant and hypoglycaemic activity of an apple complex named PCQ, with respect to other standard references. A human trial was run to confirm PCQ capacity to reduce glucose concentration, to slow down its absorption rate, to decrease the glycaemic index and promote the satiety effect.


The WHO attested that the worldwide prevalence of obesity nearly doubled between 1980 and 2008. Based on the latest estimates in European Union countries, overweight affects 30-70 percent and obesity affects 10-30 percent of adults (1). In the USA, the National Health and Nutrition Examination Survey (NHANES) has estimated that the percentage of overweight adults is dramatically increased touching 68,5 percent and the obeses are by now 34,9 percent (2). Consequently the promotion of a policy for weight control and calories intake reduction is strongly needed.
In the last decades, there has been a growing appreciation and awareness about the link between fruit and vegetables enriched diet and improved health. In particular, apple and its polyphenols have been reported to inhibit cancer cell proliferation, to decrease lipid oxidation, to lower total and LDL cholesterol levels and also to exert antioxidant and anti-inflammatory activities (3).
The apple polyphenols, including phloridzin, chlorogenic acid and quercetin, are ranked the second highest in antioxidant properties among all commonly consumed fruits and vegetables in th ...

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