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P. 18-21 /

In situ-generated chiral quaternary ammonium (hypo)iodite catalysis for enantioselective oxidative cyclisations

MUHAMMET UYANIK, KAZUAKI ISHIHARA*
*Corresponding authorNagoya University, Furo-cho, Chikusa, Nagoya, 464-8603, Japan

Abstract

Very recently, we developed the first enantioselectiveoxidative cycloetherification of ketophenols to 2-acyl-2,3-dihydrobenzofuran derivatives catalysed by in situgeneratedchiral quaternary ammonium (hypo)iodite withhydrogen peroxide or tert-butyl hydroperoxide (TBHP) as anenvironmentally benign ideal oxidant. The optically active2-acyl 2,3-dihydrobenzofuran skeleton is a key structure inseveral medicinally and biologically active compounds.