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- 10/16/2019

From ROELMI HPC, the innovative biotechnological active ingredient protecting skin microbiota – ÆCTIVE®

H&PC Today


ÆCTIVE® is a biotechnological GMO-free metabolite from selected bacterial strain showing peculiar rebalancing activity against environmental stresses. Ideal for skin microbiota equilibrium, helping the skin in remaining healthy and recovery from acute stress.

Independent from personal human microbiota composition, this innovative ingredient is able to be effective on whatever skin type, as its first target is the balancing of skin microenvironment and not the single microorganism species.

In-vitro evaluation on the maintenance of cells homeostasis after osmotic stress: human keratinocytes were treated by adding salt, chlorine and artificial sweat to the medium, showing protective effect of ÆCTIVE® on cells, compared to negative untreated control.  Results were expressed as increase of cell viability (MTT assay) and cell metabolism (total protein dosage by Lowry assay).

In-vivo double blind randomized study to evaluate ÆCTIVE®’s capacity of balancing skin microbiota and consequently enhance skin activity. On 20 adult female Chinese subjects, with healthy skin, living in Beijing, a daily application of placebo and active creams respectively in opposite side of the face. Inter-personal differences of microbiotas were reduced as the comparison was on the same subject. Metagenomics evaluation by MiSeq Illumina sequencing was done at day 0 and after 28 days, to observe the skin flora composition. In addition, skin moisturization, elasticity and profilometry were evaluated by Corneometer, Cutometer and Visioscan. Statistical analysis done by t-test.

Recent studies on skin microbiota are opening a series of future developments in personal care field. Cosmetics are no longer acting on human epidermis, but companies today are considering the effect of products on skin microbiota, which varies a lot among people. Cosmetics should treat this microorganisms community by protecting its natural stability and biodiversity, without altering its composition.

ÆCTIVE® is the innovation for cosmetic formulators to effectively protect each person’s unique and varied microbiota.

ROELMI HPC is the global expert for both active and functional ingredients in Health & Personal Care markets.

At ROELMI HPC, we believe that only the daily action with respect for the Environment could lead to a durable result. Our program NO IMPACT IN PROGRESS® (NIP) applies to all products and technologies, and it stands as a mission for every process focusing on Quality, People safety and Environment preservation.

Visit us @ Sepawa Congress 2019 – booth B407 – and do not miss our Lecture “Exploring New Applications on Personal Care: Balancing our Skin Microbiota” @ Forum for Innovation on October, 25th at 9:45am.

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