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P. 56-60 /

A capillary micro-reactor as a tool to study pressurised reactions
Theinfluence of pressure on the stereoselectivity of the Diels-Alderreaction of 2- and 3-Furylmethanol with maleimides

FERNANDO BENITO-LOPEZ1*, ALBERT J. KETTELARIJ1, RICHARD J.M. EGBERINK1, ALDRIK H. VELDERS1, ROALD M. TIGGELAAR2, HAN J.G.E. GARDENIERS2, DAVID N. REINHOUDT1, WILLEM VERBOOM1*
* Corresponding author
1. University of Twente MESA, Istitute for Nanotechnology, Supramolecular Chemistry and Technology, P.O. Box 217, Enschede, 7500 AE, The Netherlands
2. University of Twente MESA, Istitute for Nanotechnology, Mesofluidics Groups, P.O. Box 217, Enschede, 7500 AE, The Netherlands

Abstract

The influence of a pressure of 60 MPa on theconversion and the stereoselectivity of the Diels-Alderreaction of 2- and 3-furylmethanol with methyl-, benzyl-, andphenylmaleimide was studied in a capillary micro-reactor. Inthe case of 2-furylmethanol, a 1.7-fold higher conversion wasobtained at 60 MPa with respect to 0.1 MPa experiments.Pressure positively affects the formation of the exo isomer,whereas in the case of 3-furylmethanol pressure does notaffect the reaction.


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