Cryogenic lithiation reaction sand transition metal catalysis
A synergistic pairing
Low temperature reactions and transition metalcatalysis (TMC) have emerged as powerful tools in organicsynthesis in the past few years. Complex aromatic moleculescan be easily synthesized by combining the cryogeniclithiation and TMC technologies. The differences and thesynergies of these reaction types are discussed in the contextof industrial relevant molecules. The specific advantages ofthe two technologies are demonstrated on examples of thesynthesis of benzoic acid and biphenyl derivatives.