Discriminating ability of the MedDietScore in relation to gastrointestinal tract cancer A sensitivity-specificity analysis
The MedDietScore, already validated for cardiovascular and cardiometabolic disorders, was evaluated for itsaccuracy in relation to gastrointestinal cancer. 250 patients with first developed gastrointestinal cancer (63±12 years, 59.6percent males) and 250 age-sex group matched cases were studied. MedDietScore (theoretical range 0-55) and a standardized questionnaire were applied. Sensitivity, specificity and accuracy of the MedDietScore were 53 percent (95percent CI 49-57 percent), 67 percent (95 percent CI 63-71 percent) and 60 percent, respectively, for a threshold of <29/55defining “unhealthy” dietary habits. Sub-groups analyses according to gender, family history of gastrointestinal cancer andobesity, had similar results. The overall C-statistic, after adjusting for all known confounders, was 0.76. The proposed MedDietScore may be useful in the primary prevention of gastrointestinal cancer.