Folate and their health benefits
The preceding part of the article studied the production method for folates and folic acids and discussed their bio availability differences. In the following section, it is intended to discuss the role of folates and folic acid in human health and the related clinical conditions.
F, folic acid is the synthetic form; while DHF and THF are enzymatically converted to monoglutamates from polyglutamates for absorption across the small intestine.
THF. C1- active form of THF that participates in specific reactions- like, methyl- THF for methionine synthesis, formyl-THF for purine biosynthesis and so on. During methionine and purine biosyntheses, a single carbon atom is donated and THF remains unchanged. On the other hand, TMP formation needs 2 Hydrogen atoms and 1 Carbon atom. So, the product DHF must be reduced to THF by DHFR to re- enter the metabolic cycle. Bacteria and lower eukaryotes cannot take up folates from their environment, but can biosynthesize folic acid from scratch (1).
HEALTH BENEFITS OF FOLIC ACID
Folates are hydrophilic anionic molecules that do not cross biolo ... ...