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Improving organic synthesis workflow efficiency Using rapid ambient sampling mass spectrometry

PETER J. LEE*, BRIAN P. MURPHY, MICHAEL P. BALOGH, STEVEN F. EATON, JENNIFER A. BURGESS
*Corresponding author
Waters Corporation 34 Maple Street Milford, MA 01757, USA

Abstract

The Atmospheric pressure Solids Analysis Probe (ASAP), an ambientdesorption ionization technique, in conjunction with a tandemquadrupole mass spectrometer was used to directly analyze reactionmixtures of reductive amination and acylation reactions withoutreaction workup or sample cleanup. The experiments demonstratethat ASAP can be used to rapidly identify major components instarting materials, monitor reaction progresses, confirm the formationof reaction products, and identify product fractions during reactionworkup and separation.In less than one minute, the required structural information can beobtained and informed decisions made without delay. As a result,organic synthesis workflow efficiency can be enhanced throughshortened reactor and equipment turnaround times, increasedproduction yields, and a reduction in labour costs.


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